Cytochrome P-450 CYP2A6 Inhibitors (strength unknown).Compounds used in a research, industrial, or household setting.TargetĪbacavir may decrease the excretion rate of Fomepizole which could result in a higher serum level.Īceclofenac may decrease the excretion rate of Fomepizole which could result in a higher serum level.Īcemetacin may decrease the excretion rate of Fomepizole which could result in a higher serum level.įomepizole may increase the hepatotoxic activities of Acetaminophen.Īcetazolamide may increase the excretion rate of Fomepizole which could result in a lower serum level and potentially a reduction in efficacy.Īcetylsalicylic acid may decrease the excretion rate of Fomepizole which could result in a higher serum level.įomepizole may decrease the excretion rate of Aclidinium which could result in a higher serum level.įomepizole may decrease the excretion rate of Acrivastine which could result in a higher serum level.Īcyclovir may decrease the excretion rate of Fomepizole which could result in a higher serum level.Īdefovir dipivoxil may decrease the excretion rate of Fomepizole which could result in a higher serum level.Ĭategories ATC Codes V03AB34 - Fomepizole Alcohol dehydrogenase also catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites. Alcohol dehydrogenase catalyzes the oxidation of ethanol to acetaldehyde. Mechanism of actionĪntizol (fomepizole) is a competitive inhibitor of alcohol dehydrogenase.
It is formic acid that is primarily responsible for the metabolic acidosis and visual disturbances that are associated with methanol poisoning.
Methanol is first metabolized to formaldehyde and then undergoes subsequent oxidation via formaldehyde dehydrogenase to become formic acid. Glycolate and oxalate are primarily responsible for metabolic acidosis and renal damage seen in ethylene glycol toxicity. Ethylene glycol is first metabolized to glycoaldehyde which then undergoes further oxidation to glycolate, glyoxylate, and oxalate. Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.
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